For a long time I went down crazy modding rabbit holes for the fallout games, spending more time modding than actually playing. I finally decided to just pick a setup and stick with it so I could actually enjoy the game. I ended up following this guy's modlist which has a nice focus on the essentials.
I'm in the planning stages of a build that will be essentially this, a proxmox build that'll include my NAS with several hard drives (running in one VM), all my docker containers (another VM) and Linux and Windows vms with passthrough that I can spin up temporarily for games.
I think I can get the Windows VM in a place where I can also restart the whole machine and boot in natively, as a fallback for games with aggressive anti cheats that won't allow VMs, which I don't think I'll be playing much of anyway.
To answer your question, it really would be best to check game by game if the anti cheat allows VMs.
Framework is definitely not Linux only (laptops are Windows by default , but they offer a no-os option to install your own). They are however generally supportive of Linux, and it's possible that they helped make the fingerprint reader firmware work well with Linux, though I have no specific information that this was the case.
Looking at the script from the repo you installed 6.2.4. This isn't the most recent. I think you'd be fine to update (it's just extracting an exe and a couple dolls to your game directory). I've never heard of a mod requiring an older version, so staying with the most recent is probably good practice!
I definitely recommend weapon inertia and the one that makes enemies react to getting shot (can't remember the name, ragdoll maybe?). They're subtle changes but make a huge difference in how the game feels!
Yeah, I mean being able to boot either into proxmox or windows. But in proxmox, I can also open that windows install as a VM.
Some details on how it should work are here (apologies for the reddit link): https://www.reddit.com/r/VFIO/comments/aejdqk/kvm_importuse_existing_windows_install_on_disk/edqtmvb/
I definitely won't dispute that Viva New Vegas is a gold standard, but with the number of mods that even the base setup pulls in I wouldn't really call it minimal. I think the person who was asking (and me, the last time I played NV) just wanted a simple set of mods that did the most to improve the experience, which I think that list accomplished better than the others I'd looked at.
Apart from ENB, do you know what the other problems are? I'd guess mostly the result of it being a few years out of date, but genuinely curious!
I think my favorite part is how they've brought back software rendering, both by allowing it on linux and by giving the option to turn off texture filtering on opengl. That plus making the main menu look like the original release brings me right back to how I first played Half-Life!