Is 0.12ml injected weekly enough?

skymtf@lemmy.blahaj.zone to Transfem@lemmy.blahaj.zone – 21 points –

I am currently on 0.12ml (12 units) injected weekly, I don't really know if it's enough?

https://transfemscience.org/misc/injectable-e2-simulator/

I tried this but had no idea how to convert 12 units into mg, also the pharmacy does not seem to list to concentration.

https://www.empowerpharmacy.com/drugs/estradiol-valerate-injection

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It's also important to note when in your injection cycle you tested. I'm mostly interested in what my trough values will be (so immediately prior to the next injection), since that's the best approximation of steady state tissue levels. Especially on a two week injection cycle of EV, I'd be worried about my levels dipping quite low by the end of the cycle.

What concerns come with levels dropping?

For me personally, I got mood swings right before my next dose until I changed the frequency because my levels would drop. But in general, the goal with feminizing hrt is to change your hormone profile to something approximating that of a cis woman in order to get the changes you want. With a long enough gap between doses, the short half life of EV means that you'll have very low levels of estrogen right before your next injection, below your goal range.