Yubikey on Linux?

Hi friends! Has anyone here had success using Yubikeys on Linux? I've been going back and forth with support to no avail, trying to get my Yubikey 5C NFC to play nicely on Ubuntu 22.04 LTS. Any suggestions are appreciated.

I have the following Yubikey-related packages on my system:

libyubikey-udev 1.20.0-3 [Ubuntu/jammy universe]
├── is installed
└── udev rules for unprivileged access to YubiKeys

libyubikey0 1.13-6 [Ubuntu/jammy universe]
├── is installed
└── Yubikey OTP handling library runtime

python3-yubikey-manager 4.0.7-1 [Ubuntu/jammy universe]
├── is installed
└── Python 3 library for configuring a YubiKey — transitional package

yubikey-manager 4.0.7-1 [Ubuntu/jammy universe]
├── is installed
└── Python library and command line tool for configuring a YubiKey

yubikey-manager-qt 1.2.4-1 [Ubuntu/jammy universe]
├── is installed
└── Graphical application for configuring a YubiKey

yubikey-personalization-gui 3.1.24-1build1 [Ubuntu/jammy universe]
├── is installed
└── Graphical personalization tool for YubiKey tokens

libfido2-1 1.10.0-1 [Ubuntu/jammy main]
├── is installed
└── library for generating and verifying FIDO 2.0 objects

python3-fido2 0.9.1-1 [Ubuntu/jammy universe]
├── is installed
└── Python library for implementing FIDO 2.0

pcscd 1.9.5-3ubuntu1 [Ubuntu/jammy universe]
├── is installed
└── Middleware to access a smart card using PC/SC (daemon side)

UPDATE: After working my way down the entire software stack, I contacted the vendor of my USB-C port and requested a replacement. It did the trick...