What languages do you speak?
Alternatively, in the languages I speak:
Welche Sprachen sprechen Sie? (Deutsch/German)
¿Qué idiomas habla usted? (Español/Spanish)
Quelle langue parlez-vous? (Français/French)
EDIT: These sentences are now up to date.
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English natively, but I also speak Spanish every day at work. I can read and write Latin. I can exchange pleasantries in half a dozen other languages.