Breast Development in Transwomen After 1 Year of Cross-Sex Hormone Therapy: Results of a Prospective Multicenter Study

Mean breast-chest difference in centimeters over duration of CHT in months. For each time point, the mean increase in centimeters (dot) with 95% CI (bars) is shown. Data in the legend are shown as mean increase with 95% CI.

Gained bra cup sizes in 197 transwomen after 1 year of CHT. Data are shown as percentage of transwomen per cup size.

Mean breast-chest difference in centimeter over duration of CHT in months, stratified for age in four groups. (a) Weight change in three groups (b), normal weight (BMI < 25 kg/m2), overweight (25 kg/m2 ≥ BMI > 30 kg/m2), and obese (BMI ≥ 30 kg/m2) BMI (c), smokers vs nonsmokers (d), oral vs transdermal estradiol administration route (e), and four quartiles of serum estradiol levels (f). Mean serum estradiol levels in the center-specific quartiles were 110 pmol/L−1 (first quartile), 184 pmol/L−1 (second quartile), 271 pmol/L−1 (third quartile), and 452 pmol/L−1 (fourth quartile) in Amsterdam, and 142 pmol/L−1 (first quartile), 206 pmol/L−1 (second quartile), 299 pmol/L−1 (third quartile), and 567 pmol/L−1 (fourth quartile) in Ghent. For each time point, the mean increase in centimeters (dot) with 95% CI (bars) is shown.