This isn't "backfiring" though. People who were already blocking ads are the only ones doing this. If there's even a small portion of people who gave up and just started watching ads/got premium, that means YouTube won. The only way this could really be considered to have backfired is if people were stopping using YouTube entirely, which isn't really happening.
A good chunk of games DID change with it. The Unity engine makes it very simple to design games for Web. But it's also easy to make those simple games for mobile instead, which has fewer restrictions abd is more prolific. In fact, a good chunk of the bigger flash game companies migrated to mobile. There's just little demand for a web game when I can create a mobile one, monetize it more easily, and reach a larger audience by making it for mobile instead