Soulfulginger

I literally worked in a research lab working on islet cell therapies for diabetes in the US. This has actually been done many times before with cells from cadavers. It has been successful, although most the of the time the person reverts back after a few years

The issues we were trying to solve in the lab were

1. Finding a good place to transplant where the cells will last: Implanting in the hepatic region (liver), which is the most common place to implant, is toxic to the cells over time hence only lasting 3-5 years. The cells need a really good blood supply and the volume you're transplanting can't be easily transplanted in the pancreas or kidney capsules (where many successful studies were performed in mice and rats)

2. Being able to consistently make a high volume of stem cells that are fully grown into insulin producing cells: Cadaver cells usually require 3-5 donors for 1 person and require the receiver to be on lifelong immunosuppresors due to the immune response. Depending on the kind of stem cells, the patient may still even need immunosuppresors due to the cell type you're converting from

All this the say - the article says nothing about where the cells where transplanted, where they came from, or whether the person has Type 1 or Type 2 diabetes. Although it is still a feat, it is likely not the first time it has been done, and we're still a long ways off from a cure

It's definitely a drop in quality. Just look at what is out in movie theaters these days. 90% of the movies are either sequels, marvel movies, or live action remakes of films that were already made. The amount of original storytelling or unique content has dropped rapidly in the past 5 years. As someone who grew up loving going to the movie theater, it makes me so sad, and I rarely go anymore.

Whether you like or hate Barbie or Oppenheimer, they were pretty much some of the only completely brand new high production value movies that came out in the last year, which I believe is part of why they were so popular. People are craving originality, even if a lot of them don't realize it

For those who dont feel like reading the whole article, here's why:

"Much of the increase in kidney failure is caused by an ageing population. When age is taken into account, the number of people with kidney failure as a proportion of the population has remained fairly stable over the past decade, according to data from the registry."

Dr. Death was about gross negligence in medicine and the failure of the medical system to prevent unqualified doctors from making it through the system. There's no evidence that this study has anything to do with that

It sounds like if you're trying all of this and it's still not working, something about the way you're selling yourself isn't working. Have you tried changing your resume to better match different job descriptions? Try having someone give you feedback on the way you interview. Are you coming on too strong? Maybe you dont have enough specific examples in your answers or too many specifics and not enough leadership/direction. I would also use LinkedIn if you're not already

*we'll know next month

If you're going to get one, highly recommend getting 240V instead of 110v/plug and play type. 240V are the only ones that can really keep up with the heat and give you that real jet feel in the tub.

If possible, keep it somewhere covered. We have it in our covered patio, which allows us to get use of it in any kind of weather and prevents mosquitos/other bugs coming around.

Chemical balancing can be pretty tough, we mostly keep a steady supply of bleach around to make sure it's staying clean. One issue we had was the test strips never seemed to say the water was hard enough so we kept adding calcium hardner, but it ended up precipitating and making a rough coating on the seats (eventually we were able to clean it off). Ended up deciding it wasn't a big deal if some values are out of range on the test strips as long as the stuff to keep people safe is balanced (ie chlorine)

Upvoting because I want to be an awesome person

This title really overly praises him for 1) not doing much at all and 2) making changes that should have been made months ago

Ginger Hamilton is my girl 🙌

Did you use melted or soft butter? Did you refrigerate the dough before baking?

We would need to know more about the recipe and what you did while baking to know for sure

Unfortunately, that doesn't necessarily negate the requirement for immunosuppresors or some other kind of immuno protection. If it is Type 1 diabetes, the person originally became diabetic because the immune system saw certain markers on the beta cells (insulin producing cells) as a threat. So, if you recreate the beta cells, there is still a possibility that it will happen again. You are fighting your own immune system. Someone in our lab was studying encapsulation of cells to create a protective barrier around them for this very issue

If the person was Type 2, this might be less of a risk since type 2 can also be due to high insulin resistivity. There are a lot of other factors involved, though, it's not straightforward

A yearly review is generally more for them to give you feedback so you really don't have to ask questions if you don't want to. If you've been doing a decent job you have nothing to be anxious about. But here are some questions you could consider asking:

What do you consider my strengths? Is there anything I can improve on?

I would like to develop my skills in xyz, are there any opportunities in the company for me to do that? Or do you have recommendations for how I could do that outside of the company?

What are the career path options after level tech 2?

Am I meeting your expectations for where I should be at the current point in my career?

What direction do you see the company/our team moving in in the next few years? How could I help us align with that?

Really great shows have a broader plot premise and are free to build new storylines and character arcs each season. As YoBuckStopsHere said, some great shows build up and grow overtime - think Breaking Bad, Parks and Rec. Both shows start off slower, focus on character building in the earlier seasons. Then they become plot focused later on.

Other shows have the flexibility to create new story arcs so each season almost stands on its own but they still stay within the larger overarching premise, example - The Great, Game of thrones (although they really gave up at the end)

I think good shows have a plan for how to get to the end and mediocre shows do as OP described - have a beginning and end planned and not much in the middle. I don't think all shows are stuck in Act 2, but it does say something that the ones that aren't stuck there stand out that much more

Try not to be afraid of "messing things up". Fixing small holes is a great thing to learn if you own a home. A little bit of mud, sand, and paint for a nail hole really doesn't take very long and can be learned very easily through youtube videos. And if you still dont want to deal with that, you can get some command strips which are easily removable.

Hang up artwork that represents things you care about - family, travel, movies, nature. Basically, anything you look at that will make you smile when you walk in the room. Put a few indoor plants around, have coffee table books or figurines. Definitely put curtains, and have a rug is nice if you have hardwood. Anything you put up can always be removed if you decide you don't like it!

It's really inspiring to see such a wide range of hobbies in this thread

What do you even mean by this? Those issues are important, but familial hypercholemia also affects 34 million people. A treatment like this would be helpful for people across all classes

Testosterone does increase risk of heart failure so that is certainly part of it.

Women are also more risk-averse. Risky living = high chance of dying https://m.economictimes.com/magazines/panache/men-have-a-shorter-life-expectancy-than-women-thanks-to-their-genes-says-harvard-study/articleshow/99119402.cms

I only like the smaller ones and hate the bigger ones

New fear unlocked

The pancreas is not really stable enough to be implanted in at all. Other organs you're imagining like liver, stomach, heart, etc. have a solid lining that can be cut open and stitched back together. The pancreas is more like a cluster of loose cells with veins throughout and held together by a very thin, tissue paper lining. If you try to open it and insert cells, you're not going to be able to put it back together.

That's why cells are usually put in the liver, which has a large vein going directly to the pancreas. Close proximity and high blood supply. Implanting in the pancreas will likely never be an option unless you can drastically reduce the volume of cells.

Our lab was working on implanting the stem cells on a porous scaffold in the fat pad of the stomach as an alternative

I'm still confused by the need for blocking communities. Maybe it's because I use Sync, but I only subscribe to communities I'm interested in, and I use trending/new community pages to find new ones to subscribe to. My front page is my subscribed communities, so I am never subjected to all the other content I don't care about

I disagree on this one, corn tortillas are really simple if you have a press. The dough is literally just mix masa and water. And to cook them, you just put it on a hot surface for 30 seconds. Meanwhile corn tortillas from the store are always so dry and tasteless, they're rarely worth buying

If homemade mash tastes exactly like the box to you, you're doing something wrong when you make them. I'm not saying instant is bad to have in a pinch, but having the dehydrated potatos in flakes immediately makes them starchier and have a more gluey consistency. Plus, there are tons of additives that definitely make it taste different from freshly cooked potatoes.

The bad part is that their healthcare system still has to deal with the rising number of cases, but it's not like there has been an unexpected spike from anything unusual

Some countries banned plastic microbeads in 2017, so a lot of those face washes changed the formula from plastics to environmentally friendly materials. They do still make them though

None of those are mammals...

It is possible we're back on the rise. Schafrillas Productions made a great video on youtube discussing how Disney+ is basically shooting themselves in the foot by overextending their brand and fewer people are seeing Disney movies in theaters because you can just wait to see it at home anyways.

But I do think high budget films will never go back to the times of well-intentioned competition where every movie is trying to earn audiences' hearts. From now on, they will always make movies with less risk and higher profit margins regardless of whether it could be a huge hit or not, because guaranteed money will always win over creative filmmaking

Well at least if it was ransomware, the information was still probably safe. Ransomware blocks the company's access to company files by either locking the system or encrypting the files. It usually remains locked until the company agrees to pay a large fee to unlock it. So they may have lost access to that file, but the information isn't stolen, it's just unusable

I always enjoy going to art fairs and stores that have local artists' work to look for things to put up. But if you're not into art, you can also look for "wall decor" or "wall hangings " on etsy or other home furnishing sites and just look for items that will fit the vibe and color scheme of the room.

If you have a lot of space, you can also fill it with things you'll actually use. Some examples - a bar or snack cart, a nice accent chair/side table/cabinet /ottoman, a musical instrument, small fridge for drinks, an indoor firepit, shoe/coat rack

Happy decorating :)

A24 is truly a diamond in the rough, everything they make is so unique

I skin the potatoes and use a ricer. They are very smooth and creamy, not lumpy. I actually like boxed potatoes, but fresh still taste 10x better

My experience may be too anecdotal to take into account, so I understand not caring about my specific experience. But I do think it's a good idea to take life span into account, and from a quick google search the average lifespan of a Macbook air is generally 5-7 years (so really not far off).

Just something to consider that since parts aren't replaceable, OP would have to pay the full amount of a new laptop at that time

You can also just take screenshots when it pops up

Dad - a planer and bacon of the month club. Mom - athletic clothes and reservations for afternoon tea. I'm also buying tickets to an escape room for all of us to do together. Trying to give fewer gifts and spend more on activities that will bring us all together

I am not very familiar with framework but I did switch from macbooks to a dell gaming laptop years ago and I am so glad I did.

The macs are ridiculously expensive, and even if you break just the charger it costs a lot to replace. My laptop now I was able to get for nearly half the price and it runs games and programs that I used in college better than the mac ever could.

Every mac I ever owned completely died in 4-6 years of purchase. They're basically guaranteed to not last a long time. My guess is you're better off with getting a framework