I've been running Silverblue for 2 years. Apart from the hiccups mostly at the beginning of that time, things have been running very smooth and I haven't had any issues worth mentioning. Things that have been and still are hassles are e.g. missing media codecs (ffmpeg and friends) and kernel configs & modules (e.g. drivers such as nvidia). I had to learn a few new tricks with flatpak but my major use case - Steam - runs as flawless as it does on other platforms.
a git repository configured to ignore basically everything except the dotfiles. For my sway config I load configs from a symlinked folder, which points to a different config depending on the machine being configured.