I stick to games that have a Gold+ rating on ProtonDB and can't say I've run into any real issues. I use Nvidia and Endeavour have a really neat guide on how to install the drivers etc. The main reason I went with Pop OS for my laptop was because I really like their OOB setup for Gnome
Hey, doesn't work with every site but a useful tool and doesn't require any install: https://12ft.io/
All the best :)