I come from Poland and yes, totally. When I started school, and missed lessons because I was sick or whatever, I could just take the phone book and find the surname of the classmate I wanted to get notes or homework from. If there were a few surnames on the list and I didn't know their father (it was always the man of the house who was listed) first name, I could just go by who appeared to live closest to the school. Or just start calling all the numbers until I got the right one.

The target antigens are from human cells, but they are human cells that mutated and hence became cancerous. What Moderna does, is it takes DNA from these cells, sequences it and finds where exactly the mutations occurred. A mutation means that there is a different sequence of amino acids in a protein, which in effect makes it a new and distinct antigen. This way, they select antigens that are present in the melanoma cells, but not in normal cells of the body. Then they take these mutated sites and use them to generate mRNA that will encode them all, be used to synthesise these mutated antigens, and train the immune system to react to them as alien antigens. The treatment described in this article is a combination of the mRNA vaccine with Keytruda, which is a cancer therapy based on an antibody. The antibody targets a protein from the PD-1 / PD-L1 axis. This axis is used by normal cells to tell the immune system not to attack those cells, because they are body's own cells. Cancer cells often mutate like crazy, but then exploit this PD-1 / PD-L1 axis basically to say to the immune system "nothing to see here".

As for Rabies, I think we already have pretty well working vaccines, so we're not really in a dire need for new ones.

As for prions, it would be tricky. The reason prions do what they do is not that they are mutated proteins, but misfolded proteins. This is to say they assume the wrong shape, even though the sequence of amino acids in them is the same as in the healthy version of the protein. And this in turn means that they were synthesised based on a healthy, unmutated version of mRNA. And this in turn means that there is no mutation that the Moderna vaccine strategy could employ to train the immune system to recognise that prion protein.

I think the article is misleading. The studies don't seem to show that SLS causes canker sores, but if you do suffer from them, it will exacerbate them or delay their healing. The article says "studies", while only citing one study, that actually recruited patients who already suffered from the sores. A double blinded cross-over trial concluded that "The number of ulcers and episodes did not differ significantly between SLS-A, SLS-B, and SLS-free. Only duration of ulcers and mean pain score was significantly decreased during the period using SLS-free. Although SLS-free did not reduce the number of ulcers and episodes, it affected the ulcer-healing process and reduces pain in daily lives in patients with [canker sores]." Although I don't have access to the full version, so I can't view the details. By the way, SLS-A was an SLS-free toothpaste spiked with 1.5% SLS, and SLS-B was a commercially available toothpaste with 1.5% SLS in it already.

You can tell that the article is trying to sensationalise something by such phrases as:

• "But there’s no reason to accept a hazardous chemical in your toothpaste." You know what else is in your toothpaste? Sodium fluoride. Which is lethal at high enough dose. It's all about the concentration.

• "It’s strong stuff — the cleaning solution I use on our garage floor is 50% SLS." Well, yes, if you use it at concentrations ridiculously above the ones found in a toothpaste, of course it's going to be "strong stuff". You know what else is strong stuff? 100% acetic acid. Yet somehow, at 10% we happily consume it as vinegar. By the way, vinegar - great cleaning agent!

Don't get me wrong, if you're sensitive to SLS, by all means avoid it. But I'm not a fan of articles that make blanket statements about a chemical that is mostly harmful in the concentration that it's used in hygiene products. It's another one of those "aspartame gives you cancer" (which it doesn't by the way).

Wait... Did The Onion buy out CNN?

Lying. They reposted from a Reddit post that shows an eight dollar Starbucks sandwich.

I'm a morning lark, but this annoys me so much! People should be able to work whenever the F they're at their most productive, not when morning larks decided everyone should be.

Whenever my colleague at the neighbouring desk left her laptop unlocked, I would go in, and create a new Word document saying ALWAYS LOCK YOUR LAPTOP in huge red font. She vowed she would eventually get back at me.

I once took a screenshot of some random text in a Word document with "CONFIDENTIAL" as the background watermark and then I used that screenshot as my lock screen wallpaper. When I locked my laptop and left my desk, she clocked the content of my screen and thought it was finally her moment to get back at me, but... it wasn't.

Thank you for the kind reaction.

I recently moved from Reddit to Lemmy (same username) and I took my comments with me.

Breaking Bad. I heard I'm not the only one who started watching it and gave up after the first 2 or 3 episodes that were just setting the scene at a fairly slow (boring) pace. Someone had to convince me to push through them because it gets so much better. It does.

Will Smith eating spaghetti.

The new word for "whitelisted" is "allowlisted"?

So glad that Brexit brought the control back to our own hands!

Wow, never thought I'd see a headline like this. I've never had Amazon prime except for the free month trial. I had no idea it was such a problem for others that there are articles written about it.

Not just Amazon. I had a parcel being delivered by DPD while I was on holidays. I checked the delivery's webpage, which said "if you're not in, we'll leave it with your neighbour". Great!

While I was on holiday, I checked the status on the day of delivery: "you weren't in, we returned it to DPD depot". Somewhat annoying, but the depot is only 15 minute drive from mine, I can go collect it then I'm back home.

Checked it again when I got back home: "returned to sender".

The fun thing was that the item was the modem from my new internet provider, and my old provider was ceasing their services that very day.

I wonder if Biden's stepping down was partly influenced by the assassination attempt. If he hadn't, the most prominent symbol of this election would still be that image of Trump screaming "fight" while pumping his fist against the background of the American flag. But if someone from a deserted island opened a news website today for the first time, they wouldn't even know there was an assassination attempt.

I'm also a non-native speaker and I've also been taught to speak a certain way ("you and I are going" but "he saw you and me"; don't split infinitives; don't end sentences with prepositions, etc.), but then I read Steven Pinker's The Language Instinct and - even more relevant here - The Sense of Style. We've been taught to use language a certain way, but our teachers were following the prescriptivist school of thought. You say these rules were written by native folk, but it's often (if not usually) the native folk that say less when they "should" be saying fewer.

I know you said it's only mildly infuriating to you, but if proper use of language is something dear to your heart (as it is to mine) - I really recommend the above books as I think this is something not worth to get even mildly infuriated about. The border between less and fewer is fuzzier than you think and - in the words of Pinker - once you really master the distinction - that's one fewer thing for you to worry about.

Edit: typo

How do you envisage it working in practice? If a plane had a disaster that will make it crash in a matter of minutes, people wouldn't form an orderly line to jump out with their parachutes. And if the malfunction is not making the plane crash in the next 5 minutes, the plane can probably land safely at the nearest airport.

Could someone ELI5 (if possible) what passkeys actually are?

Well, I kinda agree with you, but I also kinda don't. On one hand, animals are animals, so one should either object to eating all or not object to eating any. And if one is going to make any distinctions, they should be for sentience, the ability to be miserable on a farm, and the ability to feel pain. But that means that even though you found yourself a moral foundation for objecting to dog eating while being ok with fish eating (and possibly bird eating), it's still hypocritical to object to dog eating, but not cow or pig eating (or kangaroo eating in the Oz).

On the other hand, there are things that do make dogs special. We started domesticating them about twice as long ago as we did pigs and cows. We were domesticating them for companionship, not meat, so the selection pressure favoured different traits in the domesticated wolves than it did in the domesticated auroch or boar. Which, for example, includes a special muscle that evolved in canis familiaris above its eyes to give it the ability of giving you that look that we humans can't help but interpret as cute. Also, if I recall correctly, human and their pet dog gazing into each others eyes is the only documented instance of cross-spegific interaction that leads to the secretion of oxytocin in the brains of both gazers involved.

All of this to say that, actually, I'm leaning towards the notion that there is something special about dogs, that cows and pigs don't have.

What is your 6 year old laptop's make?

Since when is twitch ad free? 🤔

Lol made me imagine firemen standing next to a burning house and drenching the one next to it with their hoses.

If you travel a lot, Toilet finder.

Edit: and not an app, but a website: Pairdrop - really useful for cross-platform file sharing, especially when you just need to email to colleagues something you snapped with your personal phone, but yoe have overly tight IT systems in place at work that stop you from connecting your personal phone to your email or OneDrive.

Can I submit an expression? "Have the work cut out for you". My thinking was "there was a lot of work, but my boss said I'll have the work cut out for me. Phew, now there's less work after some of it being cut out!"

Remember that there are biases at play here. There's the negativity bias (we worry more about bad things happening, than we are uplifted about good things happening), and the media bias to report the worst. As Pinker wrote:

News is about things that happen, not things that don't happen. We never see a journalist saying to the camera, "I'm reporting live from a country where a war has not broken out". (...) As long as bad things have not vanished from the face of the earth, there will always be enough incidents to fill the news, especially when billion of smartphones turn most of the world's population into crime reporters and war correspondents.

Combine the two, and you will naturally have all media preferentially report (and often blow out of proportion for the views and clicks) bad news over good news.

Edit: typo and grammar

• I live in the UK, so I get 25 days off work, and I take full advantage of that, I rarely do staycations.

• I'm about to buy a property and I'm deliberately going to get a mortgage where my monthly payments are not as much as I can possibly afford, but a bit less. This means that it will take me longer to pay it off, and overall it will cost me more, but I will have more disposable income today to spend on life's pleasures.

• I don't have kids and don't plan to.

• I stay physically active, just simple going to the gym 5-6 days a week. And I think this is really important. It will keep your body in shape and by the time your 60 or 70, you'll be able to do much more than your average peers who spent their middle age doing office jobs followed by evenings in front of the TV. And here, instead of my 41-year-old self, I'm going to use the example of my mum. She's turning 70 next year, but it was only when she was 68 that she started taking swimming lessons and she got to love it. It was also around that time that I floated the idea to her "why don't I take you for holidays to New York". She was all "no, no, I'm too old, it's too much walking, you took me for a holiday to London when I was 55 and I was totally exhausted, I wouldn't be able to do New York at this age." Now that she's had over 1.5 years of almost daily swimming (and cycling, she's also a keen cyclist) - she said yes. She said she's feeling perfectly fine doing long walks, she's more energised, and she already gave me a list of what she wants to see in New York.

• Other than physical activity, scientists seem to agree that the other two pillars of long and healthy life are good sleep, and good diet. For the former, I recommend reading Why we sleep by Matthew Walker. And good diet means varied diet, vegetable-rich diet, and low-calorie diet (too many books agree on that for me to recommend a specific one).

I think cadence refers only to the inflection of the pitch. A better word to describe what you seem to be talking about might be prosody.

Maybe you should cook some food and deliver it to your local KFC - would that count?

I remember the term AI being in use long before the current wave of LLMs. When I was a child, it was used to describe the code behind the behaviour of NPC in computer games, which I think is still used today. So, me, no, I don't get agitated when I hear it, I don't think it's a marketing buzzword invented by capitalistic a-holes. I do think that using "intelligence" in AI is far too generous, whichever context it's used in, but we needed some word to describe computers pretending to think and someone, a long time ago, came up with "artificial intelligence".

It's not universal though. I've been regularly doing 60-minute cardio workouts for the last 10 years or so. Not once did I experience the "runner's high". I'm pretty sure I'm an outlier though.

They should also make people watch add bofore they are handed their Amazon Prime order. Unless they pay for the higher tier subscription.

Anyway, good to know that Amazon is finally doing something to fix its fledgling revenue from Prime.

I actually can't complain. It's not perfect, but I'm far from being as outraged as the OP. I used to love SwiftKey, it was amazing with text prediction, even when you had two languages on at the same time (I'm bilingual, so it was really handy). Since Microsoft bought it, it started going downhill and when I found that I can't just transfer my settings when I get a new phone, I switched to Gboard. Again, not perfect, but not terrible either. I will try out some of the recommendation from this thread though.

I honestly have no idea what your first paragraph is about. It might as well be in Chinese.

I'm a molecular biologist. I was recently surprised when I told someone that RNA is a thing that all living thing are brimming with. He thought that RNA was something scientists invented in 2020s to use as COVID vaccines.

I also once worked with someone who had a degree in biological sciences and was shocked to learn that female cows have vaginas. She didn't explain where she thought baby cows come from, but we decided not to push the matter and changed the subject.

"OK, a few deep breaths and let's soldier through it."

I think you're amazing. Having faced such tremendous adversities at such young age, you still think that the main message you need to share is that life is fucking incredible.

I'm not a blogger or anything, so I'm sorry for posting a comment without any answers to the question in the title. But if the outlet you choose ends up being publicly available, please share the link. I would love to read whatever you think is worth writing down.

What's the TLDW for this video?

Things are getting better but painfully slowly. They don't even have recognised same sex partnerships, let alone marrieges. One of the arguments against partnerships when it was debated in the parliament a few years ago was that the word "partner" (which in Polish is also "partner") is already used in Polish and commonly means "business partner" and people would get confused which one you'd mean when you said "this is my partner". Wałęsa, the Nobel Peace Prize laureate, said of one gay activist (who at the time was an MP) that he has no place in the parliament.

That was a few years ago though, and yes there have been pride parades across the country this year, and the news articles about them don't seem to be dominated by reports of "normality parades" counter-organised by homophobes on the same day to intimidate pride parades. But I guess it's one of those changes that happen funeral by funeral...

What was this post about? Oh, right. @OP, if you're gay - don't move to Poland. At least not just yet.

That's why apparently the execution squads are told that at least one of them has blank bullets. And why two doctors do the lethal injection procedure simultaneously, but one of them is injecting saline. This way everyone can legitimately think "maybe it wasn't me who killed them". I think I read in in "Behave" by Robert M. Sapolsky.

Why? What happens to young murderers in Sweden and what impact does it have on Sweden?

I get the point of your gun analogy, but I don't think it's an apt one. It's not like only people sensitive to gunshot wounds die from gunshot wounds. If you shoot a person with a gun the damage is pretty certain. If cankers were as certain to be caused by SLS then everyone using SLS-containing toothpaste would have cankers. We don't. The bottom line is that the article linked to by OP is making misleading claims.

But I despite me not agreeing that the gunshot wound analogy is apt here, I get what you mean, so maybe the title of the lemmy post would be better phrased as something like "YSK that SLS [...] can be the cause of cankers in sensitive people". Which is also kinda the point I was trying to make in the last paragraph of my original reply.

Edit: formatting