The kernel is too old for newer AMD gpu drivers to work, but switching to a newer kernel isn't too hard. I had to when I built a new computer last winter, but I have also used various *nixes for a good long time.
Knowing how to discover you need a newer kernel is a bit tough for recent convert, though.
That's the biggest thing. apt install xyz works on my N100 based box every time I expect it will, but it was always a crapshoot on a Pi. If you don't need GPIO you don't need a Pi.