What languages do you speak?
Alternatively, in the languages I speak:
Welche Sprachen sprechen Sie? (Deutsch/German)
¿Qué idiomas habla usted? (Español/Spanish)
Quelle langue parlez-vous? (Français/French)
EDIT: These sentences are now up to date.
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Was Sprachen Sie spricht?Welche Sprachen sprechen Sie? (Deutsch/German)/\ that's the more formal way of addressing either a single person or multiple (yeah, this formal pronoun is a bit weird and can be read multiple ways). If you wanna address a group of people more informally: "Welche Sprachen sprecht ihr?".