Why do teeth don't regenerate?

Granixo@feddit.cl to No Stupid Questions@lemmy.world – 167 points –

Seems pretty dumb in our biological design to not be able to regenerate such a functional (and also easily breakable) part of our body.

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You’re saying we could reactivate the gene and get infinite teeth?? 🫨

Possible, but it may come with downsides you don't like.

Let me guess, the downside is infinite teeth.

The downside could be something that nobody has imagined yet. That is the problem with change. I'm not against this, but I demand reasonable study. (but not unreasonable levels - vaccines and GMO have been studied enough to conclude they are generally safe despite people yelling more study needed)

Side effects may include dry mouth, diarrhea, attacking swimmers at the beach. Do not take Teethenall if you are allergic to shellfish.

attacking swimmers at the beach

That I could live with.

I could be wrong, but I don't think that's how the drugs in development work. They cause the existing teeth to produce more enamel or something.

you are wrong. all their tests are on subjects missing teeth, not with reduced enamel. this is literally growing replacement teeth.

https://newatlas.com/medical/tooth-regrowing-human-trial/

Hopefully that's what it ends up being, as the idea of growing new teeth has been around in science and media for a long time.

The latest work I've seen reactivates the genes to start growing any existing teeth that had stopped. It's for early development problems in children, not for adults. But of course the media seized on the "regrow teeth" part and ran with it. Unless there's a way to implant new teeth seeds and then get them going, adults are still out of luck.

The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar.

Teeth cannot produce enamel. Enamel is not a living tissue and it was produced by cells outside of the tooth in a coral-like manner. In order to grow a new tooth, you need it to be fully surrounded by specialized living tissue for the whole growth cycle.

PS: I honestly expected something like this to come out of bioelectric computation research, but progress seems slower there. Or rather knowledge and techniques in other fields is reaching critical mass, giving us these advances.

That sorta makes it sound like a nightmare