Soon to be available for humans for the low low price of 10k per dose. Thanks to big Pharma.
MUH R&D COSTS!!!1
And then a few years later in generic form for much, much less.
I'm actually not terribly put out by the initial high cost of these things, especially when it's something that isn't a vital life-saving treatment that people have no choice but to try. Every new technology starts out expensive and gets cheaper as competition arises and better manufacturing techniques are developed.
especially when it's something that isn't a vital life-saving treatment that people have no choice but to try
last time I checked, life was terminal.
I don't see how that's relevant. This is about a drug that simulates exercise. It's a convenience drug. If you're literally dying from lack of exercise, there are other less conveninet ways to do that already.
the trend is toward life-extention beyond natural limits. this has massive social implications and I don't see anything that promises real artificial longevity ever becoming affordable by us plebs.
"Real" artificial longevity doesn't exist yet. You're jumping rather far ahead in that assumption.
pehaps, but the trend is there and its accelerating. I suspect that in short order (timeline unknown) we will actually have a legitimately marketable "life extension" option at which point its only a matter of degrees. the extra x years that you and I might possibly afford will eventually pale in comparison to the extra y years for the truly wealthy - at that point, generational wealth and power take on a wholly new and rather frightening dimension.
I admit... I may have a particularly bleak view of our possible futures, but an "undead" ruling class does not figure into any rosy endings that I can envision.
I think my "and then a few years later in generic form for much, much less" prediction would still apply here. There's always going to be demand for life-extension treatments at every wealth level, so any company that can figure out how to make it more cheaply than the others is going to have an additional market they can offer the treatment to that's further down the pay scale from the others. A pharma company wouldn't maximize profit by selling to only a handful of billionaires when they could also be selling to all the millionaires that are also out there.
I prefer my mice Reggie, thank you very much.
So meth?
yeah i'm with you this sounds like they gave mice some meth and went heeyyyyyyy weight loss
no shit
Heroin. In the right amount it actually slows aging a bit. Emphasis on THE RIGHT AMOUNT. It slows other things too, though.
Okay but what does it do with the energy from burning the fat?? Like, if you aren't moving or doing anything you just have an excess of energy going where?
In summary, the ERR agonist SLU-PP-332 functions as an exercise mimetic inducing an
acute aerobic exercise program that leads to myriad physiological adaptations that are
associated with exercise including increased skeletal muscle oxidative fibers, increased fatty
acid oxidation, and enhanced exercise endurance
Gainz
Well, waste energy is expelled as heat so… I bet they heat up. Kinda like how if you take a stimulant that raises your heart rate but you aren’t doing anything at the same time, you tend to feel warmer.
I assume that’s how it works, anyways.
We exhale fat. Maybe it makes you breathe harder as well?
Breathe thicker
So, Extremis from Iron Man 3?
So cocaine?
If you've ever done cocaine it absolutely wrecks your cardio/endurance in the long term
Who said anything about long term?
And you're a fucking lasy ass the next day and the only really chears you up is either more or shitty food.
helping mice run nearly 50% further than they could before, all without the mice lifting a paw.
I am surprised. I felt certain there would be a muscle orientation issue. Glad they are figuring this out.
Like someone on lemmy once said: tools like this will make the climate situation worse since people can eat what they want and not have to worry about gaining weight. The drug is certainly going to help a specific group of patients but it's very likely that it'll be abused.
But also will be of huge benefit to disabled folks and potentially helps solve a major issue with long term space travel
This is incredible news if you are a mouse.
Let’s hope it translates to humans without also causing cancer or some other horrible condition as all of these miracle drugs seem to.
Soon to be available for humans for the low low price of 10k per dose. Thanks to big Pharma.
MUH R&D COSTS!!!1
And then a few years later in generic form for much, much less.
I'm actually not terribly put out by the initial high cost of these things, especially when it's something that isn't a vital life-saving treatment that people have no choice but to try. Every new technology starts out expensive and gets cheaper as competition arises and better manufacturing techniques are developed.
last time I checked, life was terminal.
I don't see how that's relevant. This is about a drug that simulates exercise. It's a convenience drug. If you're literally dying from lack of exercise, there are other less conveninet ways to do that already.
the trend is toward life-extention beyond natural limits. this has massive social implications and I don't see anything that promises real artificial longevity ever becoming affordable by us plebs.
"Real" artificial longevity doesn't exist yet. You're jumping rather far ahead in that assumption.
pehaps, but the trend is there and its accelerating. I suspect that in short order (timeline unknown) we will actually have a legitimately marketable "life extension" option at which point its only a matter of degrees. the extra x years that you and I might possibly afford will eventually pale in comparison to the extra y years for the truly wealthy - at that point, generational wealth and power take on a wholly new and rather frightening dimension.
I admit... I may have a particularly bleak view of our possible futures, but an "undead" ruling class does not figure into any rosy endings that I can envision.
I think my "and then a few years later in generic form for much, much less" prediction would still apply here. There's always going to be demand for life-extension treatments at every wealth level, so any company that can figure out how to make it more cheaply than the others is going to have an additional market they can offer the treatment to that's further down the pay scale from the others. A pharma company wouldn't maximize profit by selling to only a handful of billionaires when they could also be selling to all the millionaires that are also out there.
I prefer my mice Reggie, thank you very much.
So meth?
yeah i'm with you this sounds like they gave mice some meth and went heeyyyyyyy weight loss
no shit
Heroin. In the right amount it actually slows aging a bit. Emphasis on THE RIGHT AMOUNT. It slows other things too, though.
Why is science trying to make gym-bro mice?
"In mice."
Okay but what does it do with the energy from burning the fat?? Like, if you aren't moving or doing anything you just have an excess of energy going where?
Gainz
Well, waste energy is expelled as heat so… I bet they heat up. Kinda like how if you take a stimulant that raises your heart rate but you aren’t doing anything at the same time, you tend to feel warmer.
I assume that’s how it works, anyways.
We exhale fat. Maybe it makes you breathe harder as well?
Breathe thicker
So, Extremis from Iron Man 3?
So cocaine?
If you've ever done cocaine it absolutely wrecks your cardio/endurance in the long term
Who said anything about long term?
And you're a fucking lasy ass the next day and the only really chears you up is either more or shitty food.
Yes, give it to me.
Cool. They gave speed to mice
Papers Referenced in the above article:
A Synthetic ERR Agonist Alleviates Metabolic Syndrome
https://pubmed.ncbi.nlm.nih.gov/37739806/
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity
https://pubs.acs.org/doi/10.1021/acschembio.2c00720?ref=pdf
Where can I buy several kilos? asking for a friend.
I'll be interested when it also mimics the psychological effects of working out.
Creates addiction... ?
I am surprised. I felt certain there would be a muscle orientation issue. Glad they are figuring this out.
Like someone on lemmy once said: tools like this will make the climate situation worse since people can eat what they want and not have to worry about gaining weight. The drug is certainly going to help a specific group of patients but it's very likely that it'll be abused.
But also will be of huge benefit to disabled folks and potentially helps solve a major issue with long term space travel