Two very rare Covid vaccine side-effects detected in global study of 99 million

MicroWave@lemmy.world to News@lemmy.world – 214 points –
Two very rare Covid vaccine side-effects detected in global study of 99 million
theguardian.com

Results confirm how uncommon known complications are as researchers confirm benefits from vaccines still ‘vastly outweigh the risks’

Two new but exceptionally rare Covid-19 vaccine side effects – a neurological disorder and inflammation of the spinal cord – have been detected by researchers in the largest vaccine safety study to date.

The study of more than 99 million people from Australia, Argentina, Canada, Denmark, Finland, France, New Zealand and Scotland also confirmed how rare known vaccine complications are, with researchers confirming that the benefits of Covid-19 vaccines still “vastly outweigh the risks”.

Researchers working as part of the Global Vaccine Data Network used deidentified electronic healthcare data to compare the rates of 13 brain, blood and heart conditions in people after they received the Pfizer, Moderna or AstraZeneca vaccine with the rate that would be expected of those conditions in the population before the pandemic.

60

Cue 20 million people claiming this happened to several people they know.

See, my cousin's uncle in law's boss's ex wife's nephew's tailor's butcher's 2nd cousin thrice removed's weed dealer totally had this

If my mother hears about this she's going to start screaming about blood clots again.

Incidence of thrombosis was much higher in people who contracted COVID, mind you.

Yeah and the “documentary” on it is complete bullshit.

On this note. It has happened to me, I still tell people to take it. Just not astrazenica one (I have a support group and it seems to be 90% Astrazenica) Take pfizer pls. My case is extremely extremity rare, and I was paid out by the government for it so it could be worse.

Great. Now I'm one of the assholes who knows someone. Lol. Seriously, hope things are alright now.

Haha! It's all good. I won't be normaI, but like you adjust and it becomes normal. just wish it wasn't so controversial these days.😉

Could you share what happened to you and your support group members? Just curious! If you don't want to, no worries.

Sure! I got the Astrazenica jab in my mid 20's. Even though I had previously been infected with covid; this is because I was a care worker at the time so I wanted to keep the community safe.

I started getting issues over the next week with my eyes and legs, I was having a weird pain in my eye when I moved it to the side and my legs where also painful. My GP recommended to get some blood tests done.

Before I was able to complete the blood tests I woke up one morning and was unable to pee. I spoke to my GP and they told me to go to the hospital, I was admitted and cathaterised. Over the next week and a half my condition got worse and doctors couldn't figure out what was wrong with me.

I was losing my ability to move the lower half of my body and eventually lost all feeling in it during this time, my eyesight also started going blurry.

Finally they moved me to a neurology hospital in the centre of London and figured out my condition, it was called nuromeyeltis optica. This condition is where my immune system attacked my nerves in my spinal cord and also my optic nerve.

They put me on a huge dose of steroids to stop my immune system, and used a plasma transfusion to try and flush my system of the anti bodies.

It took me months to learn to walk again, as I spent a total of 2 months in hospital and then rehabilitation.

I'm mostly normal now, you wouldn't know I was different if you saw me, other than I still have to use Cathaters to pee, suppositories to poop and my nerves still cause me great pain. So I'm really very uncomfortable tbh.

Fortunetly my eyes fixed themselves very fast, but I have a very small blind spot that honestly I don't notice.

The government paid me out via the Vaccine Damage Scheme after 2 years worth £120,000, in which they sent me a 50 page report. Stating that it was due to the vaccine and what % of disability they thought I had. It was actually between 50-80% as they weighted in mental strain very highly and my age was considered young (although a dinusour on the Internet I'm sure lmao)

Anyway that's what happened to me. It still so weird to think it's such a rare case, I'm one out of I believe 100-200 people that had a successful vaccine damage payment scheme in the UK.

I work with someone who’s convinced she got GBS from the vaccine.

They will all find the 6th degreee separated person and they’ll all claim they know the person and that one person will represent 3 million people.

Taking ANY vaccine has risks, and these vaccines even more so, considering their untested nature when they were introduced. We had to trust the science, but it was still a gamble.

I took the vaccine knowing that side effects were possible. That was a risk I felt comfortable with, knowing that everyone else who took it faced that same level of risk and uncertainty.

It sucks that some had these side effects, but the effectiveness of the vaccine has saved countless more lives.

Let’s not forget that before the vaccine, Covid was quite deadly. We had literal mass graves, trucks full of bodies, mass cremations that couldn’t keep up with the death toll. Between that and the vaccine risk… the choice was easy. We came way closer to catastrophe than we like to think about.

EVERYTHING has risks. People have choked to death on food before - that's not the reason to stop eating. There's a risk the ceiling is going to fall down on your head at any moment, but then if you go outside, there's a risk you might get hit by lightning or a bolt that fell off a Boeing flying above...

That's not a dig at you by the way - it's at people who argue in bad faith asking for 100% guarantees of safety, be it for vaccines or anything else. It is not possible, and people need to comprehend it - in this case the risk is on the level of being hit by lighting, so unless you're afraid of going outside, you shouldnt be afraid of the darn vaccine...

Precisely. Statistically, the largest risk I took when I got the vaccine was driving to the vaccination location itself that day.

10 more...

Oh great now my brother is going to quadruple down on not vaccinating any of his many kids

My mother too. Haven’t talked to her in 2 years because she went hard with me on how bad the vaccine is and challenged my college education and ability to think critically/do research, ultimately calling me gullible and stupid. It’s worth noting she dropped out of middle school and never even got her GED.

“Two things are infinite: the universe and human stupidity”

My brother should be your brother’s brother

I wouldn't be surprised if the side effects were a milder version of what those specific people would have had if they had the actual live virus.

No doubt, but the vaccine guarantees exposure and the virus does not (if you basically give up your whole life, anyway.)

There's no exposure to the virus with RNA vaccines.

Exactly, it's just a protein produced for a brief time.

Giving up life was an option, and they took the vaccine to not take that option.

Covid is and was contagious enough they were pretty much guaranteed to be exposed.

According to the conspiracy people on LinkedIn hundreds of millions of vaccinated people are already dead. I’ve had like four so I probably only have minutes to live.

Possibly I’m safe due to being in Australia, a country that doesn’t exist.

I had family members who told me the vaccine was going to kill me and various other stuff they heard from Fox News and similar.

They all caught COVID at a party in 2021 and died. Seriously. It's awful what all this conspiracy crap is doing to people. It costs lives and affects everyone around them.

It's troubling. The vaccine is obviously a bigger killer than covid ever was. The fact is 100% of all vaccine recipients will die within 1-90 years.

Wording in that headline, SUCKS.

Leading with "side effects" rather than the size/strength of the study and many readers will just ignore "very rare".

Is this the largest study of its kind? If so, lead with that as well. Outlet is purposefully flirting with this line to get clicks from both the rational and batshit sides of this "argument".

Yep this is just more fuel for antivax idiots. I'm still waiting to drop dead from the vaccine...as a few of the antivax people I have met tell me I will.

Being the petty person I can be at times, someone on ye olde reddit posted a list of people who "died from the vaccine" and listed... 23 names I think it was? I looked up all the information I could on all 23 and concluded 2 of them I couldn't definitively say what their cause of death was, but not a single one pointed to the vaccine (and a not-insignificant number wouldn't have even had access to the vaccine in their country at the time they supposedly died from it.)

I know it didn't change their mind because hand wave reasons

Yea I've literally had old coworkers who are good people, state stupid shit like this, saying how they know 5 or 6 people who personally died from the vaccine. It's insane how disconnected these people are sometimes.

Your odds of dying while swimming, running, or jogging are about the same (1 in a million). And similar to those activities, the risk exists, but the benefits vastly outweigh the risks so it's kind of irrelevant.

Acute disseminated encephalomyelitis and transverse myelitis following COVID-19 vaccination - A self-controlled case series analysis - doi: 10.1016/j.vaccine.2024.01.099. https://pubmed.ncbi.nlm.nih.gov/38350771/

Abstract

Acute Disseminated Encephalomyelitis (ADEM) and Transverse Myelitis (TM) are within the group of immune mediated disorders of acquired demyelinating syndromes. Both have been described in temporal association following various vaccinations in case reports and case series and have been evaluated in observational studies. A recent analysis conducted by The Global Vaccine Data Network (GVDN) observed an excess of ADEM and TM cases following the adenoviral vectored ChAdOx1 nCoV-19 (AZD1222) and mRNA-1273 vaccines, compared with historically expected background rates from prior to the pandemic. Further epidemiologic studies were recommended to explore these potential associations. We utilized an Australian vaccine datalink, Vaccine Safety Health-Link (VSHL), to perform a self-controlled case series analysis for this purpose. VSHL was selected for this analysis as while VSHL data are utilised for GVDN association studies, they were not included in the GVDN observed expected analyses. The VSHL dataset contains vaccination records sourced from the Australian Immunisation Register, and hospital admission records from the Victorian Admitted Episodes Dataset for 6.7 million people. These datasets were used to determine the relative incidence (RI) of G040 (ADEM) and G373 (TM) ICD-10-AM coded admissions in the 42-day risk window following COVID-19 vaccinations as compared to control periods either side of the risk window. We observed associations between ChAdOx1 adenovirus vector COVID-19 vaccination and ADEM (all dose RI: 3.74 [95 %CI 1.02,13.70]) and TM (dose 1 RI: 2.49 [95 %CI: 1.07,5.79]) incident admissions. No associations were observed between mRNA COVID-19 vaccines and ADEM or TM. These findings translate to an extremely small absolute risk of ADEM (0.78 per million doses) and TM (1.82 per million doses) following vaccination; any potential risk of ADEM or TM should be weighed against the well-established protective benefits of vaccination against COVID-19 disease and its complications. This study demonstrates the value of the GVDN collaboration leveraging large population sizes to examine important vaccine safety questions regarding rare outcomes, as well as the value of linked population level datasets, such as VSHL, to rapidly explore associations that are identified.

Keywords: Acute Disseminated Encephalomyelitis; Adverse reactions; COVID-19; Data linkage; Transverse Myelitis; Vaccination.

Study concluded that most people are fucking stupid and you shouldn't listen to them, especially when it comes to assessing risk using statistical methods.

I noticed they didn't explain things to my liking. Like why are they blaming the vaccine and not just side effects of long COVID? I was hoping they would break down the study more instead of just telling me what they think it means.

Yeah I've always been pretty doubtful of the numbers anyone gives. I've a lot of friends over four provinces and a couple northern states, moved around a lot over the last 20 years, employed in trades with a lot of free movement. I'd guess I know 30 people died due to opioids and overdoses, etc, the last 5 or 6 years. I don't know anyone died of covid.

My manager at a previous employer died of covid while I worked there. This was long after the initial hectic period.

I personally interacted with hundreds of people who would end up passing away from covid-related complications.

Obviously working in healthcare exposes you to this sort of thing more. Outside of that, I had two direct relatives who nearly died (and likely would have if they had caught it when DME companies had run out of oxygen concentrators to rent out in 2020)

Nothing you said is untrue, but none of is is relevant either. You even seem to know that.

It’s relevant because it’s largely regional or circumstantial. The distribution of Covid deaths depends heavily on healthcare system capacity and population density, and when it was bad, it was really bad.

Yeah too many of these hospitals were closed to the public and pretending to be full while nearly empty. Heart attack deaths disappeared statistically. Just a big pile of BS. Just ask a nurse after a few beer.

Definitely not in my neck of the woods, unless they had thousands of crisis actors at every hospital in my area.

The fuck does your comment have anything to do with COVID vaccine side-effects?!

Also, "I'm doubtful of the numbers anyone gives" Proceeds to give his numbers

Okay? They're meaningless if we assume everyone has your opinion regarding numbers.

You really need someone to explain why his personal and wide ranging experience across a quarter of a continent involving thousands of people would make him question the numbers, when people he's knows personally vaguely resemble the stats of the one crisis for their regions, and the people he knows personally do not whatsoever resemble the official numbers in another? This wasn't complicated.

And if you looked around outside your bubble at all you'd see that Covid has killed more people than the Holocaust. By a significant margin. Including several of my family members. Fuck off with your denialism, millions have died because of attitudes like yours.

The numbers are lies and it's really fucking obvious. I'm sorry about your family members but it doesn't change that.

If only the willfully ignorant were the only ones suffering, I wouldn't care about your opinion. You have the right to go die choking on your own phlegm, doesn't bother me. But spreading misinformation kills people. You are killing people. You are a murderer by proxy. I hope with all my heart that you reap the appropriate rewards of that.

You might have convinced me a while ago. No one of any intelligence buys this crap anymore